The V-1000 small animal ventilator is an easy-to-use ventilator designed by Yuyan Company specifically for mice, rats, and other small animals. The volume mode provides a fixed tidal volume during each breath, while the pressure mode stops inflation at a preset airway pressure. In capacity mode, the ventilator follows the principle of time flow, knowing that the airflow passes through within a certain period of time, and thus obtaining the corresponding volume passed through. In pressure mode, the airflow is simply adjusted to provide a suitable suction time. The actual tidal volume is displayed on the LCD screen, as well as the minute ventilation volume (MV) and other respiratory parameters are displayed on the screen. The built-in air pump can operate without the need for an additional air source. This pump sucks in indoor air, oxygen, or anesthetic gas through the port on the rear panel.

V-1000 has simple control and intuitive data. The respiratory rate (RR) is directly set and displayed as breaths per minute. The inhalation to exhalation ratio depends on the setting of inhalation time. All parameter settings can be operated through touch screen. After adjustment, the LCD screen will automatically update and display the new flow rate and corresponding tidal volume. The pressure mode and capacity mode can be switched through touch screen operation. In any mode, the front panel pressure bar gauge will continuously display the current airway pressure. This pressure signal can also be exported as external recorded data. The automatic sighing function can be set by pressing the sighing function.

Product features:

1. Accurate control, stable performance, easy operation, and durability;
2. Ultra quiet design to reduce experimental noise;
3. Built in air pump, using air as the gas source, no need for high-pressure gas, easy to use;
4. External oxygen or anesthetic gas can be used as the gas source to form a complete respiratory anesthesia system;
5. Multiple adjustable and controllable respiratory parameters: respiratory rate, ventilation volume, airway pressure, inspiratory ratio, pressure trigger threshold, sigh trigger threshold, etc;
6. Pressure control mode: Airway pressure control range: 0-50cmH2O;
7. Capacity control mode: tidal volume adjustment range 0-100ml, step by 0.1ml;
8. Equipped with sigh breathing function, adjustable range of sigh cycle: 0-999;
9. The sighing function has the ability to regulate breathing through sighing, which is more effective than adjusting it separately;
10. The working parameters can be changed at any time during the operation of the ventilator;
11. Equipped with a medical grade 5-inch IPS LCD screen, resolution: 720 * 1280;
12. Able to display various ventilation parameters, such as respiratory rate, tidal volume, respiratory ratio, minute ventilation volume, sigh pressure, airway pressure;
13. Real time display of airway pressure waveform;
14. Equipped with shuttle control knob: convenient for parameter adjustment during surgery;
15. Equipped with inhalation light, exhalation light, and inhalation maintenance LED light, it can display instantaneous ventilation pressure and facilitate real-time monitoring of the operation status of the ventilator;
16. Equipped with a specially designed oral endotracheal tube, achieving non-invasive respiratory intubation without the need for tracheal suturing surgery after surgery;
17. Equipped with a USB data interface for remote control and triggering settings in conjunction with the imaging system;

Application areas:

Suitable for small experimental animals such as rats, mice, guinea pigs, and rabbits, it can be used for scientific research experiments in basic medicine, clinical medicine, and animal medicine (such as myocardial ischemia model production, lung function assessment), as well as respiratory management, animal emergency treatment, respiratory therapy, etc. in animal clinical procedures.

model: V-1000

The main configuration of V-1000 small animal ventilator:

According to the requirements, the SAR-1000 small animal ventilator can also be selected

·Carry positive end expiratory pressure to ensure lung filling and maintain it until the end of exhalation;

·Terminal inspiratory pause can improve the efficiency of gas exchange and respiration in animal lungs;

·In capacity mode, precise control of ventilation volume is possible;

·In pressure mode, the airflow can also be adjusted to the appropriate inhalation time;

·On the LCD display, not only can the actual calculated tidal volume be intuitively displayed, but also the number of breaths per minute and other respiratory parameters can be displayed;

·The built-in air pump operates independently and can switch between air, oxygen, or anesthetic gases;

Main models:

·SAR-1000, universal type for rats and mice

·SAR-830AP, rat guinea pig model

·CTP VA, rabbit model expansion adapter

model: SAR-830AP

model: SAR-1000

Respiratory adapters for rabbits, monkeys, and other animals weighing less than 10Kg

Multi channel respiratory adapter

Main features and advantages:

·Pressure or capacity cycling operation;

·Wide range of tidal volume and velocity;

·Humanized design, simple and convenient operation;

·Standard configuration for mice and rats;

·Adding an adapter can be used for animals weighing less than 10kg, such as rabbits and monkeys;

·Directly display tidal volume and other respiratory parameters on the LCD screen;

·Can be remotely controlled through USB interface;

Mouse respiratory tract

Rat respiratory tract

Comparison of technical parameters for multiple models of ventilators:

Can also cooperateRat laryngoscope、Tracheal intubation platformInsert non-invasive tools into the trachea of rats and mice through the mouth.

Rat and mouse laryngoscopes

Tracheal intubation platform

CG-02M type, suitable for mice, outer dimensions: 20 * 15 * 20cm

CG-02R type, suitable for rats, outer dimensions: 22 * 21 * 28cm

CG-04M model, mouse specific style

reference:

1. Sun, Zhenxing et al. “Myocardium-targeted transplantation of PHD2 shRNA-modified bone mesenchymal stem cells through ultrasound-targeted microbubble destruction protects the heart from acute myocardial infarction.” Theranostics vol. 10,11 4967-4982. 6 Apr. 2020, doi:10.7150/thno.43233

2. Zhang, Li et al. “Localized Delivery of shRNA against PHD2 Protects the Heart from Acute Myocardial Infarction through Ultrasound-Targeted Cationic Microbubble Destruction.” Theranostics vol. 7,1 51-66. 1 Jan. 2017, doi:10.7150/thno.16074

3. Cai, Heng et al. “Mild Hypothermia Promotes Ischemic Tolerance and Survival of Neural Stem Cell Grafts by Enhancing Global SUMOylation.” Oxidative medicine and cellular longevity vol. 2022 6503504. 27 May. 2022, doi:10.1155/2022/6503504

4. Zhang, Xuerui et al. “Dominant Negative FADD/MORT1 Inhibits the Development of Intestinal Intraepithelial Lymphocytes With a Marked Defect on CD8αα+TCRγδ+ T Cells.” Frontiers in immunology vol. 9 2038. 10 Sep. 2018, doi:10.3389/fimmu.2018.02038

5. Ma, HaiXiang et al. “Dorsal raphe nucleus to pre-Bötzinger complex serotonergic neural circuit is involved in seizure-induced respiratory arrest.” iScience vol. 25,10 105228. 27 Sep. 2022, doi:10.1016/j.isci.2022.105228

6. Ren, Wenbo et al. “Moderate hypothermia induces protein SUMOylation in bone marrow stromal cells and enhances their tolerance to hypoxia.” Molecular medicine reports vol. 16,5 (2017): 7006-7012. doi:10.3892/mmr.2017.7425

7. Zhang, X-G et al. “Investigating the expression of miRNA-133 in animal models of myocardial infarction and its effect on cardiac function.” European review for medical and pharmacological sciences vol. 23,13 (2019): 5934-5940. doi:10.26355/eurrev_201907_18338

8. Wang, Juntao et al. “Protective effects of dexmedetomidine on lung in rats with one-lung ventilation.” Experimental and therapeutic medicine vol. 17,1 (2019): 187-192. doi:10.3892/etm.2018.6952

9. Qing, Hua et al. “Regulation of adventitial interstitial fluid circulation by heartbeat and respiration.” bioRxiv doi:10.1101/2022.10.18.512678

10. Han Yue, Diao Yugang, Song Dandan, etc Improvement of the model of cardiac arrest during extracorporeal circulation in bloodless pre filled rats [J]. Chinese Journal of Extracorporeal Circulation, two thousand and twenty

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