1、 Product Introduction

GI-3000XYBlood drug concentration analyzerBy accurately detecting and analyzing the drug components and concentrations in the blood of patients taking medication, it is possible to determine the individual metabolic environment information of the patient from the results, thereby providing scientific data support for designing the best treatment plan and medication dosage tailored to the patient, in order to achieve the maximization of treatment effect and minimize side effects. This detection method has high accuracy, fast results, and simple operation. The system integrates hundreds of drug components and their concentration determination methods for treating mental disorders, epilepsy, tumors, antibiotics, cardiovascular diseases, vitamins, etc., providing scientific support for the development of precision medicine plans for patients with major and chronic diseases who require long-term and precise treatment, as well as children's healthy growth and development. This system is also suitable for clinical drug analysis and research of common drugs.

IIBlood drug concentration analyzerTechnical innovation and progressiveness of products

1. A new type of two-dimensional liquid interface processing technology has been innovatively invented, which completes purification, extraction enrichment, storage, separation and analysis online, with high detection accuracy and the ability to detect trace amounts of the tested drug and its content in blood samples. The detection limit of the instrument has been raised to the level of 1 * 10-9.

2. We have innovatively developed a specialized equipment for blood drug concentration detection based on two-dimensional liquid chromatography technology. The system is fully intelligent, with powerful pre-processing capabilities and equipped with rich drug testing analysis methods. It has a high degree of specialization and can perform automated batch testing. From the hardware part of the detection system, the chromatographic control software part, to the onboard drug testing method, it is designed and produced specifically for the blood drug concentration detection of clinical therapeutic drugs. It is specialized and meets the needs of clinical therapeutic drug testing.

3. We have innovatively developed ultra-high pressure resistance technology for constant flow pumps. The constant flow pump adopts a new structural design and new materials and process technology, which increases the pressure resistance from 45MPa to 100MPa. Using efficient separation technology, the detection speed is 8 times faster than conventional liquid chromatography, the detection sensitivity is increased by 5 times, the separation degree is increased by more than 2 times, the chromatographic peak height is increased by more than 1 time, and the anti leakage performance index of the constant flow pump is also improved.

4. The chromatography workstation software adopts two-dimensional liquid phase parallel processing technology, combined with ultra-high pressure technology in the hardware system, enabling the secondary liquid phase system of the detection system to process work in parallel, further shortening the drug testing time to 5-10 minutes and greatly improving work efficiency.

5. The automatic injection system adopts high-pressure injection and mobile phase needle passing technology, without the need to clean the inner wall of the injection needle, resulting in less sample residue, increasing from less than 0.05% to less than 0.005%, and improving the reproducibility of the system. The current method used is semi-automatic injection with a quantitative ring, which requires manual replacement of the quantitative ring.

6. A series of rich clinical drug concentration detection methods have been developed and configured for various specialties in the hospital, greatly facilitating user operation and enabling laboratory research equipment to enter clinical testing use.

7. The third-generation liquid chromatography technology using precision screw drive is significantly superior to traditional cam belt drive technology. The core unit of the constant current pump adopts high-pressure constant current pump technology driven by dual independent servo motors and ball screws, which can improve system performance, reliability, stability, and durability.

8. The stroke of the constant flow pump can be adjusted arbitrarily, allowing gradient mixing to be completed inside the pump. The equipment eliminates the independent gradient mixer, reducing the dead volume to a smaller degree and improving the repeatability index and detection speed of the equipment

9. The detector adopts a high-speed data acquisition device with 24 bit AD conversion and signal sampling frequency of 80hz, ensuring low noise, low drift, ultra-high sensitivity, and improving the resolution and accuracy of the spectrum

10. Upgradeable multiple detector technologies with internationally advanced Ampere detector and Coulomb array detector technology products, laying the foundation for the detection of various complex drug components. The sampling frequency of the UV detector is 80HZ

11. Equipped with a 5-inch 16:9 TFT high-resolution touch color screen (800 * 480 dot matrix) control and computer software full reverse control functions

12. The use of a new type of photoelectric conversion and amplification circuit effectively reduces noise.

Rich detection and analysis methods

We have collaborated with domestic universities and research institutions to develop over a hundred drug analysis and testing methods, including antiepileptic drugs, antipsychotic drugs, anti-tumor drugs, anti tuberculosis drugs, antibiotics, immunosuppressive drugs, sedative drug overdose analysis, antifungal drugs, biomarkers, and other self built analysis methods

Excellent 2D front-end processing
1. Complex samples, such as lean meat, plant leaves, roots, and stem soaking solutions; Urine, cerebrospinal fluid, etc. require almost no treatment;
2. Non uniformly complex samples, such as blood samples, only require simple homogenization or no processing;
3. All analysis of small molecule substances does not require the use of organic solvents for extraction and does not emit polluting organic gases;
4. Completely disposable design, the process from sample reception to sample measurement completion, without the need to clean any consumables;
5. The mobile phase does not require filtration and can be directly configured in the mobile phase bottle;
6. Multi channel selection function, quick switching of analysis types, convenient for the determination of various small molecule substances.

Adapt to user initiated methods
1. It has multiple online processing modes to meet the diverse needs of complex samples with complex matrix components and simple matrix components;
2. Integrate multiple sample import systems for fully automated small molecule substance determination;
3. Capable of online dialysis, online processing, online analysis, and online data acquisition, meeting the in-depth needs of small molecule substance process analysis;
4. Can be used in conjunction with mainstream brand detectors, including optical detectors, electrochemical detectors, mass spectrometry detectors, etc., to complete various scientific research tasks;
5. Template measurement method guidance system, convenient for users to independently develop methods.

Detection range
1. Psychiatric drugs
2. Antiepileptic drugs:
3. Antitumor drugs:
4. Antibiotics
5. Cardiovascular drugs
6. Immune preparations:
7. Hypnosis and sedation:
8. Vitamins:
9. Other categories: monoamine, analgesic drugs, hormone drugs, anti tuberculosis drugs, circulatory system, gastrointestinal drugs or other drugs, etc.

Four major achievements of project implementation:
1. Effect 1: Improved the professional level of doctors, providing scientific basis and data support for the rapid and accurate development of precision medical plans.
2. Effect 2: Supporting the development of hospital scientific research. The introduction of large-scale medical scientific instruments into hospitals helps to improve the level of hospital scientific research equipment and facilitates the research and development work of medical researchers.
3. Effect 3: Significant social benefits. The improvement of equipment grade and medical level has enhanced the hospital's external image and implemented the national policy of strongly supporting precision medicine.
4. Effect 4: Significant economic benefits. The drug concentration analyzer is a highly profitable detection instrument.